What’s New in Parkinson’s Medications: A Guide to the Latest Treatment Options
Parkinson’s disease is a progressive neurological condition that affects movement, coordination, and sometimes mood and thinking. While there’s no cure yet, exciting advances in medication have given patients more options than ever before to manage their symptoms and improve quality of life. If you or a loved one has been diagnosed, understanding the landscape of new Parkinson’s medications can help you have better conversations with your medical team.
⚠️ Important: This article is for informational purposes only. Always talk to your neurologist or primary care physician before starting or changing any medication.
A Quick Refresher on How Parkinson’s Medications Work
Most Parkinson’s symptoms are caused by a loss of dopamine-producing neurons in the brain. Many medications work by either replacing dopamine, mimicking its effects, or helping the brain use it more efficiently. Some new Parkinson’s medications go beyond this approach by targeting non-motor symptoms or offering longer-lasting effects.
1. Rytary (extended-release carbidopa/levodopa)
Levodopa remains the gold standard for Parkinson’s, but one common frustration is the “on/off” cycle—periods where the medication stops working between doses. Rytary is a newer formulation of carbidopa/levodopa that uses extended-release technology to provide smoother symptom control throughout the day.
Why it’s helpful: Fewer motor fluctuations and less frequent dosing
Good to know: It may take time to adjust the dose for each individual
2. Ongentys (opicapone)
Ongentys is a once-daily COMT inhibitor used alongside levodopa to prevent its breakdown, helping it stay active longer in the body.
Why it’s helpful: Helps extend “on” time (when symptoms are controlled)
Side effects: Can include involuntary movements (dyskinesias), nausea, or insomnia
3. Inbrija (inhaled levodopa)
Sometimes symptoms return suddenly and unexpectedly. Inbrija is a rescue therapy—an inhalable form of levodopa that provides quick relief during “off” episodes.
Why it’s helpful: Works in as little as 10 minutes to restore mobility
Best for: Patients already on carbidopa/levodopa who experience sudden symptom return
4. Nourianz (istradefylline)
Nourianz is a non-dopaminergic drug that works by blocking adenosine A2A receptors, a different pathway in the brain that’s involved in motor control.
Why it’s helpful: Can reduce “off” time when taken alongside standard therapy
Unique aspect: Doesn’t work by affecting dopamine directly, so it’s a good add-on
5. Nuplazid (pimavanserin)
Many people with Parkinson’s experience hallucinations or delusions, especially in later stages. Nuplazid is the first FDA-approved medication specifically for Parkinson’s disease psychosis.
Why it’s helpful: Treats hallucinations without worsening motor symptoms
Important note: This is not used for general confusion or memory loss
How These Medications Fit Into Parkinson’s Care
Each person with Parkinson’s is different, and the ideal treatment plan depends on symptoms, age, other medical conditions, and lifestyle. New Parkinson’s medications allow doctors to customize treatment more than ever before—whether that means extending “on” time, reducing side effects, or addressing symptoms like anxiety, tremors, or hallucinations.
Don’t Go It Alone—Talk to Your Medical Team
The best first step is always a conversation with your neurologist. If your current medication doesn’t seem to be working as well, or if new symptoms are showing up, it may be time to adjust your plan. Your doctor may also recommend therapy services, exercise programs, or referrals to specialists like speech or occupational therapists.
⚠️ Disclaimer: This article is not a substitute for medical advice. Always talk to your physician before making any changes to your medication or treatment plan.
How Mind & Mobility Can Help
Medication is just one part of effective Parkinson’s care. At Mind & Mobility, we provide in-home and outpatient therapy services that work alongside your medical treatment. Whether you’re starting LSVT BIG therapy, working on balance, or learning energy conservation strategies, our certified therapists can help you stay independent and active.